https://www.mbl.edu/blog/first-gene-knockout-in-a-cephalopod-is-achieved-at-mbl/ First Gene Knockout in a Cephalopod is Achieved at MBL July 30, 2020 WOODS HOLE, Mass. —A team at the Marine Biological Laboratory (MBL) has achieved the first gene knockout in a cephalopod using the squid Doryteuthis pealeii, an exceptionally important research organism in biology for nearly a century.
The team used CRISPR-Cas9 genome editing to knock out a pigmentation gene in squid embryos, which eliminated pigmentation in the eye and in skin cells (chromatophores) with high efficiency.